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重度吸烟可引起体液和细胞免疫功能多种改变,此改变与重度吸烟者感染和肿瘤发生率升高呈因果关关系。作者以前曾研究过吸烟(无癌症)对NK活性的影响。本文则比较了非吸烟者、吸烟者及肺癌病人的NK活性。用~(51)Cr释放法测定NK细胞活性,共检测68人外周血的NK活性,其中非吸烟健康志愿者22人为对照组。按吸烟程度分组:每年累积吸烟≤49包为轻度/中度吸烟(15人),≥50包为重度吸烟(12人)。结果表明,吸烟者的NK活性(29.5±23.8%)比不吸烟者(43.4±17.3%)显著降低(P<0.02)。轻度吸烟者的NK活性(41.3±22%)与非吸烟者相似,而重度吸烟者的NK活性(14.7±15.7%)显著低于轻度吸烟者(P<0.002)。肺癌病人的平均NK活性(19.3±13.7%)分别显著低于非吸烟者(P<0.001)
Severe smoking can cause a variety of changes in humoral and cellular immune functions, and this change is related to a causal relationship between severe smokers’ infection and increased incidence of cancer. The author previously studied the effect of smoking (no cancer) on NK activity. This article compares NK activity in non-smokers, smokers, and lung cancer patients. The activity of NK cells was measured by ~(51)Cr release method. The NK activity in peripheral blood was detected in 68 people. Among them, 22 non-smoking healthy volunteers were control group. According to the degree of smoking, cumulative smoking is ≤49 packs per year for mild/moderate smoking (15), and ≥50 packs for severe smoking (12). The results showed that the smoker’s NK activity (29.5±23.8%) was significantly lower than the non-smoker (43.4±17.3%) (P<0.02). The NK activity (41.3±22%) of mild smokers was similar to that of non-smokers, while the NK activity of severe smokers (14.7±15.7%) was significantly lower than that of mild smokers (P<0.002). The average NK activity in lung cancer patients (19.3±13.7%) was significantly lower than that of non-smokers, respectively (P<0.001).