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真核细胞翻译起始因子是调节蛋白质翻译的关键因素,作为mRNA帽结合磷蛋白,过度表达能使一些肿瘤相关恶性基因的蛋白质表达量发生变化,引起致癌性改变。笔者就eIF4E在乳腺癌中的表达、作用以及治疗研究的最新研究进展作一综述。
Eukaryotic cell translation initiation factor is a key factor in regulating protein translation. As an mRNA cap binding to phosphoprotein, overexpression can change the protein expression of some tumor-associated malignant genes and cause carcinogenic changes. The author reviews the expression and role of eIF4E in breast cancer and the latest research progress of therapeutic research.