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目的探讨介入治疗在老年高危冠脉综合征患者中的远期疗效。方法选取2005年1月～2009年8月在某院检查诊断为冠脉综合征的患者中的140例老年高危ACS患者作为观察对象,其中根据患者意愿及病情进行介入治疗者70例(介入治疗组),根据研究对象可比性原则选取常规药物保守治疗患者70例(保守治疗组)作为对照组,进行观察两组患者远期治疗效果。结果两组患者MACE发生率、猝死率、术后严重出血发生率随着时间延长发生几率逐渐增高,术后半年、1年保守治疗组患者各项指标发生率稍高于介入治疗组患者,但各项观察指标之间差异无统计学意义(P﹥0.05);术后2年,保守治疗组死亡率高于术后严重出血量低于介入治疗组,两组之间差异有统计学意义(P﹤0.05)。结论高危老年急性冠脉综合征患者早期及时进行介入治疗可以有效的降低MACE发生率,提高患者生存率,术后抗凝药物的使用要个性化并且控制好剂量,以防出现严重出血。
Objective To investigate the long-term efficacy of interventional therapy in elderly patients with high-risk coronary syndrome. Methods One hundred and seventy elderly patients with high-risk ACS were enrolled in this study. One hundred and seventy elderly patients with high-risk ACS diagnosed as coronary syndrome in a hospital from January 2005 to August 2009 were selected. Among them 70 patients were treated according to their wishes and their condition (interventional therapy Group). According to the principle of comparability of study objects, 70 conservative treatment patients (conservative treatment group) were selected as the control group, and the long-term treatment effect was observed in both groups. Results The incidence of MACE, the rate of sudden death and the incidence of postoperative severe bleeding increased gradually with time in both groups. The incidence of various indicators in the conservative treatment group was slightly higher than that in the interventional therapy group at six months and one year after operation There was no significant difference between the two groups (P> 0.05). After 2 years of operation, the mortality rate of the conservative treatment group was higher than that of the postoperative serious bleeding volume less than the intervention group, the difference was statistically significant P <0.05). Conclusions Interventional treatment of high-risk senile patients with acute coronary syndrome can reduce the incidence of MACE and improve the survival rate of patients. The use of anticoagulant drugs should be personalized and well controlled to prevent severe bleeding.