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降黑素(N—乙酰甲氧色胺)是松果腺分泌的物质:并且很快地代谢为6—羟基降黑素。在小鼠此代谢产物约占注入的同位素标记降黑素的70—80％。羟化的代谢产物是以硫酸盐或尿苷酸结合物而排泄的。人尿中该代谢产物的定量分析可以提供松果腺的合成和释放降黑素的综合测定。本文是用气相色谱/质谱仪联合分析测定人尿中降黑素的代谢产物—6—羟基降黑素。观察了7个成年男性志愿受试者,平均年龄为35岁(21—52岁),连续观察三天,每隔六小时收集一次尿。他们是在
Melanin (N-acetyl-methoxytryptamine) is a substance secreted by the pineal gland: and is rapidly metabolized to 6-hydroxymelanin. This metabolite in mice accounts for about 70-80% of the injected isotope labeled melanin. Hydroxylated metabolites are excreted as sulfate or uridylate conjugates. Quantitative analysis of this metabolite in human urine can provide a comprehensive assay for the synthesis and release of pineal gland to reduce melanin. This article is the simultaneous determination of 6-hydroxy melanin, a metabolite of melanin, in human urine by gas chromatography / mass spectrometry. Seven adult male volunteers were observed with an average age of 35 years (21-52 years) and were observed continuously for three days and urine was collected every six hours. They are here