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目的:观察中药附子对慢性心力衰竭大鼠血流动力学、血浆血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)及左室重量指数的影响,并从现代医学的角度探讨其作用机制。方法:结扎大鼠冠状动脉前降支制成慢性心力衰竭模型,以卡托普利为阳性对照药,随机分组,分别予附子大剂量、小剂量、卡托普利治疗或空白治疗,造模成功21天后开始灌胃给药,连续给药4周,并于观察末测血流动力学,用放免法检测血浆血管紧张素Ⅱ、醛固酮;计算左室重量指数。结果:附子和卡托普利均可改善血流动力学,主要改善心脏收缩功能,附子大剂量组优于附子小剂量组和卡托普利组,附子小剂量组与卡托普利组无明显差异。附子无抑制循环RAAS系统,卡托普利有抑制循环RAAS系统的作用。附子不能降低左室重量指数,卡托普利能显著降低左室重量指数,附子大剂量可以显著升高左室重量指数。结论:附子可以显著增强慢性心力衰竭心脏收缩力,具有明显的量效关系;附子大剂量可能有加剧左室重构的作用。
Objective: To observe the effect of aconite on hemodynamics, plasma angiotensin Ⅱ (Ang Ⅱ), aldosterone (ALD) and left ventricular mass index in rats with chronic heart failure and to explore its mechanism from the perspective of modern medicine. Methods: The model of chronic heart failure was established by ligation of the anterior descending coronary artery in rats. Captopril was used as a positive control and was randomly divided into high dose, low dose, captopril treatment or blank treatment. 21 days after the successful start of intragastric administration, continuous administration for 4 weeks, and to observe the end of the measured hemodynamics, radioimmunoassay of plasma angiotensin Ⅱ, aldosterone; calculated left ventricular mass index. Results: Both aconite and captopril can improve hemodynamics, mainly improve cardiac contractility, high-dose aconite group is superior to the aconite low-dose group and captopril group, aconite low-dose group and captopril group Significant differences. The aconite does not inhibit the circulatory RAAS system, and captopril has the effect of inhibiting the circulatory RAAS system. Aconite can not reduce the left ventricular mass index, captopril can significantly reduce the left ventricular mass index, high doses of aconite can significantly increase the left ventricular mass index. Conclusion: Aconite can significantly improve cardiac contractility in patients with chronic heart failure, with a significant dose-effect relationship; high doses of aconite may aggravate the role of left ventricular remodeling.