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目的：探讨血清降钙素原（PCT）、超敏C反应蛋白（Hs－CRP）及动脉血气水平联合应用对慢性阻塞性肺疾病急性加重期（AECOPD）伴肺动脉高压的临床诊断价值。方法选取76例AECOPD患者进行研究，其中40例确诊为AECOPD伴肺动脉高压患者作为研究组，36例单纯型AECOPD的患者为对照组。观察并比较两组患者血清PCT、Hs－CRP与动脉血氧分压（PaO2）、二氧化碳分压（PaCO2）水平，评价PCT、Hs－CRP及动脉血气水平对AECOPD的诊断价值。结果研究组PCT、Hs－CRP、PaCO2水平均显著高于对照组，PaO2水平显著低于对照组（P均＜0．05）。PCT、Hs－CRP、PaO2诊断AECOPD伴肺动脉高压的敏感性分别为87．86％、81．12％、90．74％，特异性分别为72．31％、57．83％、75．87％；三者联合诊断的敏感性为96．52％，特异性为82．36％，均高于各单项指标诊断效率。结论 PCT、Hs－CRP、PaO2对AECOPD伴肺动脉高压患者均有一定的诊断意义，但三项指标联合诊断具有更高的敏感性和特异性，对AECOPD伴肺动脉高压的早期确诊具有更高的参考价值。“,”Objective To investigate the clinical value of high sensitive C-reactive protein (Hs-CRP) and procalcitonin (PCT) combined with arterial blood gas for the diagnosis of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with pulmonary hypertension (PH).Methods From June 2014 to December 2015,seventy-six patients with AECOPD received in our hospital were involved in the study. Forty cases of AECOPD with PH were defined as the research group, while thirty-six of AECOPD without PH as the control group. The levels of PCT,Hs-CRP and arterial blood gas of the two groups were observed and compared, and the value of the indicators in the diagnosis of AECOPD with PH was evaluated. Results The serum PCT, Hs-CRP and PaCO2 in the research group were significantly higher than those of the control group; PaO2 was significantly lower than that of control group (P<0.05). The diagnostic sensitivities for AECOPD with PH of PCT, Hs-CRP and PaO2 were 87.86%, 81.12% and 90.74%, respectively; the specificities of these indicators were 72.31%, 57.83% and 75.87%, respectively. The sensitivity and specificity of PCT and Hs-CRP combined with PaO2 in diagnosis for AECOPD with PH were 96.52% and 82.36%, respectively, which were higher than those of each individual indicator. Conclusions PCT, Hs-CRP and PaO2 alone could be used as the indicator of diagnosis for AECOPD with PH. However, these three indicators used together for the diagnosis of AECOPD with PH has higher sensitivity and specificity.