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目的评价肝动脉栓塞化疗术联合口服单药替吉奥在大肠癌肝转移中的疗效和安全性。方法将68例大肠癌肝转移患者随机分为两组,观察组32例,给予肝动脉栓塞化疗术联合口服替吉奥,对照组36例,给予肝动脉栓塞化疗术。观察两组患者的治疗效果和不良反应。结果观察组有效率为50.00%,对照组有效率为22.22%(P<0.05),观察组患者12,24,48个月生存率分别为90.63%,75.00%,21.88%,均高于对照组(P<0.05);两组患者治疗后均未出现严重并发症。结论 TACE联合口服替吉奥是治疗结直肠癌肝转移安全、有效的方法,值得临床应用。
Objective To evaluate the efficacy and safety of transcatheter hepatic arterial chemoembolization (TACE) in combination with oral single-agent tegaserod in the treatment of liver metastasis of colorectal cancer. Methods Sixty-eight patients with liver metastasis of colorectal cancer were randomly divided into two groups. The observation group consisted of 32 patients. The patients in the observation group received hepatic arterial chemoembolization combined with oral administration of TEGO. The control group received 36 patients with hepatic arterial chemoembolization. Observation of two groups of patients with treatment and adverse reactions. Results The effective rate was 50.00% in the observation group and 22.22% in the control group (P <0.05). The survival rates in the observation group at 12, 24 and 48 months were 90.63%, 75.00% and 21.88%, respectively, which were higher than those in the control group (P <0.05). No serious complications occurred in both groups after treatment. Conclusion TACE combined with oral tioguanide is a safe and effective method for the treatment of liver metastasis of colorectal cancer, which is worthy of clinical application.