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为探索日本血吸虫（中国大陆株）２２．６ｋＤａ 抗原（Ｓｊ２２．６）编码基因用作核酸疫苗的可行性，将ｐＣＭＶ／Ｓｊ２２．６基因重组质粒经肌肉注射免疫了一批ＢＡＬＢ／ｃ小鼠并进行攻击感染试验，结果表明此重组质粒能在小鼠体内持续存在、稳定表达并诱导小鼠产生特异性的抗Ｓｊ２２．６ 抗体，但未能诱导有效的保护力
In order to explore the feasibility of using the gene encoding 22.6kDa antigen (Sj22.6) of Schistosoma japonicum (Chinese mainland strain) as a nucleic acid vaccine, a batch of BALB / c mice were immunized with recombinant plasmid pCMV / Sj22.6 by intramuscular injection The results showed that the recombinant plasmid could persist in mice and stably express and induce specific anti-Sj22.6 antibodies in mice, but failed to induce effective protection