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促胃液素瘤(苏-艾氏综合征,Zollinger-Ellison Syndrome),1955年由Zollinger-Ellison两氏首先报告2例这样的病人:暴发型溃疡病,反复做胃切除术后复发,胃酸分泌多,有胰腺非β岛细胞瘤(NON-βislet cell tumor)。当时认为是由这种瘤产生的内分泌,即高血糖素引起此病。现知胃酸分泌过盛和临床其他症状是由此瘤产生的促胃液素(Gastrin)引起的,故称促胃液素瘤。因为有些病人无苏-艾氏综合征症状,无溃疡,仅有腹泻或脂性下泻,胃酸过多不显著,与一般十二指肠溃疡难分别。近年来由于广泛应用血液和组织中促胃液素的免疫测定(Immunoassay),对此瘤的诊断已比较容易和肯定。胰性霍乱(Pancreatic Cholera)有类似的腹泻,它是由胰岛癌产生的内分泌,但不是促胃液素引起的。
Gastrointestinal tumor (Zollinger-Ellison Syndrome), first reported in 1955 by Zollinger-Ellison two of such patients: fulminant ulcer disease, repeated gastrectomy recurrence, gastric acid secretion and more , Pancreatic non-beta island cell tumor (NON-betaislet cell tumor). It was thought to be caused by this tumor endocrine, that glucagon cause the disease. It is known that excessive gastric acid secretion and other clinical symptoms caused by this tumor gastrin (Gastrin) caused, it is called gastrinoma. Because some patients without Su-Ehrlich syndrome symptoms, no ulcers, only diarrhea or lipid-lowering, hyperacidity is not significant, and difficult to distinguish the general duodenal ulcer. In recent years due to the widely used blood and tissue gastrin immunoassay (Immunoassay), the diagnosis of this tumor has been relatively easy and sure. Pancreatic Cholera has similar diarrhea, which is endocrine produced by pancreatic cancer but is not caused by gastrin.