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目的:探讨重度外阴阴道假丝酵母菌病(VVC)合理规范有效的治疗方案。方法:选择120例重度VVC患者并随机分为A、B两组。A组60例,口服伊曲康唑200 mg/d,连续3天,同时阴道局部使用硝酸咪康唑阴道软胶囊1 200 mg,1次/3天,2日疗法。B组60例,A组方法+以后于月经干净后阴道局部使用硝酸咪康唑阴道软胶囊1 200 mg,连续用药3个月经周期。结果:A、B两组近期疗效显著,差异无统计学意义(P>0.05);远期疗效两组比较差异有统计学意义(P<0.05),B组复发率明显低于A组。结论:伊曲康唑和硝酸咪康唑联合用药优化治疗方案,能明显提高重度VVC的远期疗效,防止VVC的复发。
Objective: To investigate the rational and effective treatment of severe vulvovaginal candidiasis (VVC). Methods: 120 patients with severe VVC were selected and randomly divided into A and B groups. A group of 60 patients, oral itraconazole 200 mg / d for 3 days, while vaginal topical miconazole nitrate vaginal soft capsule 1 200 mg, 1/3 days, 2 days therapy. Group B, 60 cases, group A method + after the menstrual clean vaginal use of miconazole nitrate vaginal soft capsule 1200 mg, continuous medication 3 menstrual cycle. Results: The short-term curative effect was significant in group A and group B, with no significant difference (P> 0.05). There was significant difference between the two groups in long-term curative effect (P <0.05). The recurrence rate in group B was significantly lower than that in group A. Conclusion: Itraconazole and miconazole nitrate combination therapy optimized treatment can significantly improve the long-term efficacy of severe VVC to prevent the recurrence of VVC.