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目的:探讨上皮性卵巢癌组织中细胞肉瘤蛋白(Cell sarcoma,c-Src)的表达及其其临床意义。方法:通过Western blotting方法检测4例正常卵巢组织及21例上皮性卵巢组织中c-Src蛋白的表达。同时,通过免疫组化的方法检测26例正常卵巢组织和134例上皮性卵巢癌组织中c-Src的表达。统计分析c-Src的表达与上皮性卵巢肿瘤的临床病理因素之间的关系。结果:与正常卵巢组织相比,上皮性卵巢癌组织中c-Src蛋白的表达明显增高。c-Src蛋白的过表达与上皮性卵巢癌患者的临床病理分期、组织学分化程度、淋巴结转移情况及肿瘤复发之间差异存在统计学意义(P<0.05),但与患者的年龄等因素均无显著相关性(P>0.05)。此外,c-Src蛋白的高表达,与上皮性卵巢癌患者的预后密切相关(P<0.05)。结论:c-Src在上皮性卵巢癌组织中过表达,且与肿瘤的恶性生物学行为密切相关,可能作为评估上皮性卵巢癌恶性程度、病情进展的重要指标及分子靶向疗法的新靶点。
Objective: To investigate the expression of cell sarcoma (c-Src) in epithelial ovarian cancer and its clinical significance. Methods: Western blotting was used to detect the expression of c-Src protein in 4 cases of normal ovarian tissue and 21 cases of epithelial ovarian tissue. At the same time, the expression of c-Src in 26 cases of normal ovarian tissue and 134 cases of epithelial ovarian cancer was detected by immunohistochemistry. Statistical analysis of the relationship between c-Src expression and clinicopathological factors in epithelial ovarian tumors. Results: Compared with normal ovarian tissue, the expression of c-Src protein in epithelial ovarian cancer was significantly increased. There was a significant difference between the overexpression of c-Src protein and the clinicopathologic stage, histological grade, lymph node metastasis and tumor recurrence in epithelial ovarian cancer patients (P <0.05), but not with age No significant correlation (P> 0.05). In addition, the high expression of c-Src protein is closely related to the prognosis of patients with epithelial ovarian cancer (P <0.05). CONCLUSIONS: Overexpression of c-Src in epithelial ovarian cancer tissues is closely related to the malignant biological behavior of epithelial ovarian cancer. It may serve as a new target for assessing the malignancy and progression of epithelial ovarian cancer and molecular targeted therapy .