免疫反应的遗传控制是现代免疫学研究的重要内容,近年来进展十分迅速。早已发现机体的免疫反应受遗传控制,但直到60年代末才确认,控制免疫反应的基因(Immune Response Gene,Ir基因)存在于MHC基因复合体中。近十多年来,对Ir基因的研究取得了突出的进展。本文综述小鼠H-2相关的Ir基因的研究概况。 1938年,Gofer等发现,不同的纯系小 The genetic control of immune response is an important part of modern immunology research, and the progress has been very rapid in recent years. It has been found that the body’s immune response is genetically controlled, but it was not confirmed until the late 1960s that the Immune Response Gene (Ir gene) is present in the MHC gene complex. In recent ten years, the research on Ir gene has made outstanding progress. This article reviews the research overview of mouse H-2-related Ir genes. In 1938, Gofer et al. Found that different pure lines were smaller