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目的 了解血清同型半胱氨酸 (Hcy)水平与年龄、冠状动脉 (冠脉 )病变支数及冠心病不同类型之间的关系。 方法 采用横断面调查的方法收集行冠状动脉造影术的年龄≥ 6 0岁 (老年组 )者 16 6例 ,年龄低于 6 0岁 (非老年组 )者 16 1例 ;从健康查体人群中选取 6 3人做为健康对照组 ,用高效液相色谱测定血清Hcy水平。 结果 冠心病患者男性的比例、年龄及血清Hcy水平高于非老年组冠心病患者 ;老年组冠心病患者的血清Hcy〔(17 6 3± 7 12 ) μmol/L〕水平低于非老年组〔(2 0 82± 13 31) μmol/L〕 ,P <0 0 5 ;老年组冠心病患者的女性比例 (2 8/ 16 6 )明显高于非老年组的比例 (8/16 6 ) ,且P <0 0 5。老年组与非老年组患者Hcy水平明显高于非冠心病组 (P <0 0 1)。老年组 2支及 3支病变组Hcy水平高于 1支病变组 (P <0 0 5 )。进一步观察Hcy水平与冠心病不同类型之间的关系发现 ,老年组冠心病不同类型之间的Hcy水平差异无显著性 (P >0 0 5 )。 结论 血清Hcy升高、男性和年龄是导致冠脉病变的重要而独立的危险因素之一 ,年龄对血清Hcy水平有一定的影响 ;Hcy水平轻度升高做为判断冠状动脉病变严重程度的指标在老年组冠心病患者有一定意义 ;做为判断冠心病的不同临床类型的指标在非老年组冠心病患者?
Objective To understand the relationship between serum homocysteine (Hcy) level and age, coronary artery (coronary) lesion count and different types of coronary heart disease. Methods Totally 16 6 patients aged 60 years or older (aged group) undergoing coronary angiography were enrolled in this study. Among them, 16 1 were younger than 60 years old (non-elderly) Sixty-three healthy individuals were selected as control group, and serum Hcy level was measured by HPLC. Results The proportion of men with coronary heart disease and the serum Hcy level were higher than those of non-elderly patients with coronary heart disease. The serum Hcy level of patients with coronary heart disease (17 6 3 ± 7 12 μmol / L) in elderly patients was lower than that of non-elderly patients (20 82 ± 13 31) μmol / L], P <0.05. The proportion of women with coronary heart disease in the elderly group (28/166) was significantly higher than that in the non-elderly group (8/16 6) P <0 0 5. Hcy levels in elderly patients and non-elderly patients were significantly higher than those in non-CHD patients (P <0.01). Hcy levels in 2 and 3 lesions in the elderly group were higher than those in 1 disease group (P <0.05). Further observation of the relationship between Hcy levels and different types of coronary heart disease found that there was no significant difference in Hcy between different types of coronary heart disease in elderly patients (P> 0.05). Conclusions The serum Hcy, male and age are the important and independent risk factors of coronary artery disease. Age has a certain effect on serum Hcy level. Hcy level is slightly increased as the index to judge the severity of coronary artery disease In the elderly group of patients with coronary heart disease has a certain significance; as indicators to determine the different clinical types of coronary heart disease in non-elderly patients with coronary heart disease?