论文部分内容阅读
循环免疫复合物(以下简称CIC)的形成是正常机体免疫反应的一部份,有利于破坏和清除对机体有害的抗原。但在某些特殊情况下,如抗原物质的持续存在或机体清除复合物的机能减退,GIC就可沉积于组织,激活一些生物活性因子,引起组织损伤,导致发生免疫复合物性疾病,如:血清病、类风湿性关节炎、系统性红斑狼疮等。目前已建立了多种检测CIC的技术,并为深入研究CIC的致病机制,监视免疫复合物病的复发和恶化,以及判断预后,观察疗效,提供了有用的工具。 CIC的检测技术可分为抗原特异性和抗
The formation of circulating immune complexes (hereinafter referred to as CIC) is part of the normal immune response, is conducive to the destruction and removal of antigens harmful to the body. However, in some special cases, such as the persistence of antigenic substances or the diminished function of the body scavenging complex, GIC can deposit on the tissue, activate some bioactive factors, cause tissue damage, resulting in immune complex diseases such as serum Disease, rheumatoid arthritis, systemic lupus erythematosus and the like. At present, a variety of techniques for detecting CIC have been established and provide useful tools for further studying the pathogenesis of CIC, monitoring the relapse and worsening of immune complex diseases, and judging the prognosis and observing the curative effect. CIC detection technology can be divided into antigen-specific and anti-