较多文献报道,AIDS患者有明显的免疫抑制,尤其是细胞免疫。表现为外周血淋巴细胞减少,辅助和抑制T细胞比例倒置,细胞毒T细胞和自然杀伤细胞功能降低,T淋巴细胞对有丝分裂原和特异性抗原的体外应答缺陷。然而,对AIDS患者中性粒细胞和单核-巨噬细胞非特异性免疫防御系统的研究尚不多见。作者对16名男性同性恋AIDS患者进行了外周血单核细胞和中性粒细胞功能的测定。首先以酪蛋白和用酵母聚糖A激活新鲜人血清制得的补体裂解物C5a(ZAS)为趋化因子,检查AIDS患者单核细胞的趋化作用。结果表明,其趋化反 More literature reports, AIDS patients have obvious immunosuppression, especially cellular immunity. Manifested by peripheral blood lymphopenia, ancillary and inhibitory T cell inversion, decreased cytotoxic T cell and natural killer cell function, and T lymphocyte response to mitogenic and specific antigens in vitro. However, the research on the nonspecific immune defense system of neutrophils and monocyte-macrophages in AIDS patients is still rare. The authors tested 16 peripheral blood mononuclear cells and neutrophils in patients with homosexual AIDS. First, the chemoattractant C5a (ZAS), made from casein and human serum activated by Zymosan A, was used as a chemokine to examine chemotaxis of monocytes in AIDS patients. The results show that the chemotaxis