硝苯吡啶是一种钙通道拮抗剂,能阻滞钙离子介导的电机械偶联作用,从而既引起冠状动脉也引起外周动脉的扩张,它已成功地用于各种心血管疾病,尤其是心肌缺血综合征和高血压。但它对心肌有直接的负性肌力作用,这与它能阻滞心肌细胞的跨膜钙离子转运有关. Nifedipine is a calcium channel antagonist that blocks the calcium-mediated electromechanical coupling that causes both the coronary arteries and the peripheral arteries to dilate. It has been successfully used in various cardiovascular diseases, especially Is myocardial ischemia syndrome and hypertension. But it has a direct negative inotropic effect on the myocardium, which is related to its ability to block transcellular calcium transport in cardiomyocytes.