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Transmission Control Protocol (TCP) optimization in Mobile Ad hoc NETworks (MANETs) is a challenging issue because of some unique characteristics of MANETs. In this paper,a new end-to-end mechanism based on multiple metrics measurement is proposed to improve TCP performance in MANETs. Multi-metric Measurement based Enhancement of TCP (MME-TCP)designs the metrics and the identification algorithm according to the characteristics of MANETs and the experiment results. Furthermore, these metrics are measured at the sender node to reduce the overhead of control information over networks. Simulation results show that MME-TCP mechanism achieves a significant performance improvement over standard TCP in MANETs.