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疏水修饰的水溶性聚合物的聚合两亲性分子,在水相中能够通过分子间和分子内的疏水部分之间的相互交联自发的形成胶束或自聚集体。这种纳米级自组织体有一些独特的性质,如特异的流变学属性,相当窄粒径分布,核壳结构,比低分子量表面活性剂更低的临界聚集浓度(CAC)以及热力学稳定性等(Akiyoshi et al.,1996;Kuroda et al.,2002;Kim et al.,2005)。最近,来自天然多糖的自聚集纳米粒由于其良好的生物相容性,生物可降解性,低毒副作用受到人们的特殊关注(Kim et al.,2006)。Kwon等(2003)以胆固醇为疏水基共价链接到乙二醇壳聚糖上,这种两亲性分子在水液中可以自聚集形成纳米球,而且这种纳米球可以作为潜在的疏水药物和蛋白的载体。
Polymeric amphiphilic molecules of hydrophobically modified water-soluble polymers are capable of spontaneously forming micelles or self-aggregates in the aqueous phase through inter-molecular and intramolecular hydrophobic interactions. This nanoscale self-assembly has some unique properties such as specific rheological properties, rather narrow particle size distribution, core-shell structure, lower critical aggregation concentration (CAC) than low molecular weight surfactants, and thermodynamic stability (Akiyoshi et al., 1996; Kuroda et al., 2002; Kim et al., 2005). Recently, self-aggregated nanoparticles from natural polysaccharides have received special attention due to their good biocompatibility, biodegradability and low toxicity (Kim et al., 2006). Kwon et al. (2003) covalently linked cholesterol glycol to glycol chitosan. These amphipathic molecules self-assemble into aqueous nanoparticles to form nanospheres, and this nanosphere can be used as a potential hydrophobic drug And protein carrier.