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目的探讨在复治涂阳肺结核患者中实施左氧氟沙星配合抗结核方案治疗的临床价值。方法通过随机对照法将近3年到我院治疗的54例复治涂阳肺结核患者等分成两组,对照组27例单纯予抗结核(3HRZE/6HRE)方案治疗,观察组27例增加左氧氟沙星用药,研究两组的临床防治情况。结果观察组用药后的病灶吸收率、痰菌阴转率分别达到85.2%和96.3%,相比对照组的59.3%和63.0%明显增高,有统计学意义(P<0.05),用药期间虽有毒性症状出现,但两组的发生率比较相当,不具统计学意义(P>0.05)。结论对复治涂阳肺结核患者实施左氧氟沙星与抗结核方案共同治疗,疗效更加理想、安全,更利于促进病灶吸收,适合加强推广。
Objective To investigate the clinical value of levofloxacin plus anti-tuberculosis regimen in patients with relapsed and smear-positive pulmonary tuberculosis. Methods 54 cases of retreatment smear positive pulmonary tuberculosis who were treated in our hospital for nearly 3 years were divided into two groups by randomized controlled trial. The control group was treated with 3HRZE / 6HRE regimen. In the observation group, 27 cases were treated with levofloxacin, Study of two groups of clinical prevention and treatment. Results The absorption rate of the lesion and sputum negative conversion rate in the observation group were 85.2% and 96.3% respectively, which were significantly higher than those in the control group (59.3% and 63.0%, P <0.05) Toxic symptoms appear, but the incidence of the two groups is quite comparable, not statistically significant (P> 0.05). Conclusion The combination of levofloxacin and anti-TB regimen in patients with relapsed and smear-positive pulmonary tuberculosis is more effective and more effective in promoting the absorption of the lesion, which is suitable for strengthening the promotion.