论文部分内容阅读
目的为了早期发现油泥砂集中流化焚烧处理工艺作业工人的早期职业健康损害情况,从而予以有效的干预措施,以降低职业性疾患的发生率。方法以油泥砂处理厂20名作业人员作为试验组,日常工作不接触或很少接触职业病危害因素的20名其他工作人员作为对照组。采用比色法检测血清中丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)及超氧化物歧化酶(SOD)的活力;采用自动生化分析仪测定血常规;采用石墨炉原子吸收光谱法检测尿总铬含量;采用硝酸酶还原法测定痰液中NO2-/NO3-含量。结果油泥砂集中流化焚烧项目作业工人尿中总铬含量、血清中MDA含量高于对照组(P<0.01)。SOD活力及痰液中NO2-/NO3-含量分别为(9.83±8.82)mg/g肌酐、(4.46±1.08)nmol/ml、(97.5±16.7)U/ml和(60.30±34.51)μmol/L,与对照组的(3.53±1.65)mg/g肌酐、(2.01±0.64)nmol/ml、(110.0±17.4)U/ml、(36.90±21.28)μmol/L相比,差异均有统计学意义(P<0.05和P<0.01)。结论油泥沙作业工人尿总铬含量、痰液中NO2-/NO3-含量、血清中MDA含量及SOD活力可作为油泥砂集中流化焚烧处理作业工人健康监护的早期指标。
OBJECTIVE In order to find out the early occupational health damage of workers in the fluidized bed incineration treatment of sludge, the effective intervention measures should be taken to reduce the incidence of occupational diseases. Methods Twenty workers in the oil and sand treatment plant were used as the experimental group, and 20 other workers who did not touch or had little exposure to occupational hazards were selected as the control group. The activity of malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in serum were detected by colorimetric method. The blood routine was determined by automatic biochemical analyzer. The content of total chromium in urine was detected by furnace atomic absorption spectrometry. The content of NO2- / NO3- in sputum was determined by nitrate reductase method. Results The concentration of total chromium in urine and the content of MDA in serum of workers in the concentrated fluidized incineration of oil sands were higher than those in the control group (P <0.01). The activity of SOD and the content of NO2- / NO3- in sputum were (9.83 ± 8.82) mg / g creatinine (4.46 ± 1.08) nmol / ml, (97.5 ± 16.7) U / ml and (60.30 ± 34.51) μmol / (3.51 ± 1.65) mg / g creatinine (2.01 ± 0.64) nmol / ml, (110.0 ± 17.4) U / ml and (36.90 ± 21.28) μmol / L respectively in the control group) (P <0.05 and P <0.01). Conclusion The total urinary chromium content, NO2- / NO3- content in sputum, MDA content in serum and SOD activity of oil-silt workers can be used as early indicators of health monitoring of workers in concentrated fluidized incineration.