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目的:旨在探讨如何有效预防高原地区早产儿呼吸窘迫综合征(NRDS)的发生。方法:对在2008年12月—2010年12月两年间我院产科分娩的75例孕周在28+3W～34W之间,出生体重在1 000g～2 300g之间,无出生窒息史的早产儿,随机分为两组,治疗组(39例)与对照组(36例),两组患儿在相同常规护理治疗基础上,治疗组在患儿生后2小时即进行预防性NCPAP(鼻塞式持续气道正压通气)辅助呼吸支持治疗,两组均未用肺表面活性物质,经统计学分析研究NRDS的发生率、常频呼吸机使用率、死亡率。结果:治疗组NRDS发生10例(25.6%);6例(15.4%)进行了常频呼吸机治疗,死亡1例(2.6%);对照组NRDS发生18例(50.0%);16例(44.4%)进行了常频呼吸机治疗,死亡3例(8.3%);两组在NRDS的发生率、常频呼吸机使用情况经统计学分析,P<0.05,两组有显著差异。结论:我院采用早产儿从出生后即开始应用NCPAP辅助呼吸治疗预防NRDS的发生受到了良好效果,同时减少了常频呼吸机的使用,继而缩短了早产儿用氧时间。此方法对预防高原地区早产儿NRDS的发生起到了一定的作用,临床值得推广。
Objective: To explore how to effectively prevent the occurrence of respiratory distress syndrome (NRDS) in preterm infants in the plateau area. Methods: During the two years between December 2008 and December 2010, 75 cases of gestational weeks in our hospital were between 28 ± 3W and 34W, and the birth weight was between 1 000g and 2 300g. There was no premature birth asphyxia The children were randomly divided into two groups: treatment group (39 cases) and control group (36 cases). Two groups of children under the same routine nursing treatment were treated with prophylactic NCPAP Type of continuous positive airway pressure) adjuvant respiratory support therapy, both groups did not use pulmonary surfactant, the statistical analysis of the incidence of NRDS, frequent ventilator use, mortality. Results: NRDS occurred in 10 (25.6%) and 6 (15.4%) patients in the treatment group, respectively. One patient (2.6%) died of NRDS, 18 (50.0% %) Were treated with CPT and died in 3 cases (8.3%). The incidence of NRDS and the use of CPT in both groups were statistically analyzed (P <0.05). There were significant differences between the two groups. Conclusion: Prenatal treatment of preterm infants with NCPAP-assisted respiration therapy has been effective in preventing preterm birth of NRDS in preterm infants. At the same time, it reduces the use of CPT and shortens the duration of oxygen consumption in preterm infants. This method has played a certain role in preventing the occurrence of NRDS in the highland area, which is worthy of clinical promotion.