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白细胞介素35(IL-35)是IL-12家族成员之一,主要发挥抗炎及免疫抑制作用。IL-35是调节性T细胞发挥最大抑制效应所必需的一种抑制性细胞因子,IL-35诱导的调节性B细胞在自身免疫性和感染性疾病中也发挥关键调控作用。自身免疫性疾病的小鼠模型研究结果提示,IL-35可通过IL-10依赖的机制在调控免疫反应性方面发挥作用,重组型IL-35可增强自身免疫调控,推测IL-35在人类疾病中也有相似的作用,并对IL-35的靶向治疗充满期待。现就IL-35的结构、功能以及在人类自身免疫性疾病方面的研究进展进行综述。
Interleukin 35 (IL-35) is a member of the IL-12 family and exerts anti-inflammatory and immunosuppressive effects. IL-35 is an inhibitory cytokine necessary for the maximal inhibitory effect of regulatory T cells, and IL-35-induced regulatory B cells also play key regulatory roles in autoimmune and infectious diseases. The results of a mouse model of autoimmune diseases suggest that IL-35 plays a role in the regulation of immunoreactivity through an IL-10-dependent mechanism. Recombinant IL-35 may enhance the regulation of autoimmunity. It is speculated that IL-35 may play an important role in human diseases Also have similar effects, and full of expectation for the targeted therapy of IL-35. This review summarizes the structure, function, and research progress of IL-35 in human autoimmune diseases.