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近几年来开始注意到钙拮抗剂对脑血管有选择性扩张作用,广泛用于治疗脑血管障碍。 1.钙拮抗剂对正常脑血管和脑循环的作用:在离体条件下,钙拮抗剂能抑制去甲肾上腺素、5-羟色胺、K、Ca等所引起的脑血管收缩,尤其对抑制PGF_2α、血栓素、儿茶酚胺等引起的脑血管收缩,较对其它末梢动脉的选择性更为明显,此种选择性的作用机理包括:同一收缩物质对不同部位的动脉作用有差异;抑制脑血管细胞内贮存钙的释放等。
In recent years, it has been noticed that calcium antagonists have a selective dilation effect on cerebrovascular and are widely used for the treatment of cerebrovascular disorders. 1. The effect of calcium antagonists on normal cerebrovascular and cerebral circulation: In vitro, calcium antagonists can inhibit cerebral vasoconstriction caused by norepinephrine, 5-hydroxytryptamine, K, Ca, especially on the inhibition of PGF 2α , Thromboxane, catecholamines and other causes of cerebral vasoconstriction, compared with other peripheral arterial more obvious selectivity, this selective mechanism of action: the same contraction of different parts of the role of arteries are different; inhibition of intracranial cells Storage of calcium release and so on.