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目的 :研究乳腺浸润性导管癌生长方式的体视学参数对判断预后的价值。方法 :根据体视学原理 ,采用模板法 ,测定 3 4 3例乳腺浸润性导管癌的癌实质体积密度 (Vv)及癌巢的表面积密度 (Sv) ;观察H .E .切片进行淋巴结癌转移计数 ;以Bloom Richardson和Elston分级法进行组织学分级。比较Vv、Sv、淋巴结转移情况及组织学分级与预后的关系。结果 :癌实质体积密度 (Vv)及癌巢的表面积密度 (Sv)中 ,Sv≤ 4 4患者 89 3 %生存 5年以上 ,称安全型 ,Sv >5 5患者 82 5 %死于 5年以内 ,称危险型。此外 ,Sv <1 8患者 ,均生存 5年以上 ,Sv >9 4患者均死于 5年以内。此分类结果Sv正判率 89 2 6%、灵敏度 (SE) 0 92 5 0、特异度 (SP) 0 82 93。结论 :癌肿生长方式的体视学参数—Sv值可作为独立判断预后的指标
Objective : To study the value of stereological parameters of invasive ductal carcinoma of breast in judging the prognosis. METHODS: According to the stereological principle, the method was used to determine the parenchymal bulk density (Vv) and surface area density (Sv) of cancer infiltrating ductal carcinoma in 343 patients. The H.E. section was taken for lymph node metastasis. Count; Histological grades using Bloom Richardson and Elston grading. The relationship between Vv, Sv, lymph node metastasis, histological grade and prognosis was compared. RESULTS: Among the cancer bulk density (Vv) and surface area density (Sv) of cancer nests, 89. 3% of patients with Sv ≤ 4 4 survived more than 5 years and were classified as safe. 82 55% of patients with Sv > 5 died within 5 years. , known as dangerous type. In addition, Sv <18 patients all survived for more than 5 years, and Sv> 94 patients all died within 5 years. The classification result of Sv positive rate 89 2 6%, sensitivity (SE) 0 92 5 0, specificity (SP) 0 82 93. Conclusion : The stereological parameters of tumor growth pattern, Sv value, can be used as independent predictors of prognosis.