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目的研究中国河北地区汉族人群PADI4基因padi4_94位点多态性及其分布特征。方法选取河北地区汉族健康个体106例和类风湿关节炎(RA)患者115例,采用直接测序法对padi4_94位点单核苷酸多态性进行分析,探讨此位点SNP与抗CCP抗体产生的关系。结果本地区汉族人群padi4_94位点存在AA、AG和GG等3种基因型,健康组与RA组的基因频率及等位基因频率无明显区别,且这种SNP并不对RA患者抗CCP抗体的存在产生影响。结论中国河北地区汉族人群padi4_94位点存在多态性,但可能不影响RA的易感性以及抗CCP抗体的产生。
Objective To investigate the polymorphism and distribution of PADI4 gene at the padi4_94 locus in Hebei Han population of China. Methods A total of 106 Han healthy individuals and 115 rheumatoid arthritis patients were enrolled in this study. The single nucleotide polymorphisms at padi4_94 locus were analyzed by direct sequencing. The SNPs in this locus and anti-CCP antibody relationship. Results There were 3 genotypes of AA, AG and GG in padi4_94 locus of Han nationality in this region. There was no significant difference in gene frequency and allele frequency between healthy group and RA group, and this SNP did not have anti-CCP antibody in RA patients Have an impact. Conclusion There is polymorphism in padi4_94 locus in Han population of Hebei Province of China, but it may not affect the susceptibility of RA and the production of anti-CCP antibody.