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目的:观察并分析乙二胺四乙酸二钾(EDTA-K2)诱导血小板假性减低。方法:对于乙二胺四乙酸二钾诱导血小板假性减低病例采用EDTA-K2抗凝、枸橼酸钠抗凝及手工法计数,并涂片染色镜检。结果:EDTA-K2抗凝静脉血与枸橼酸钠抗凝静脉血、手工法的血小板检测结果均存在统计学差异(P<0.05);枸橼酸钠抗凝静脉血与手工法的血小板检测结果无统计学差异(P>0.05);并且,EDTA-K2抗凝静脉血的血小板随时间延长而持续降低。结论:EDTA-K2抗凝剂可致某些患者血小板聚集,而导致血小板计数明显降低。遇此情况应涂片染色镜检确认,并用枸橼酸钠抗凝静脉血检测血小板。
Objective: To observe and analyze the false reduction of platelets induced by EDTA-K2. Methods: EDTA-K2 anticoagulation, sodium citrate anticoagulation and manual methods were used for the cases of pseudo-platelet hypodensity induced by dipotassium EDTA, and smear microscopy. Results: There were significant differences in the platelet count between EDTA-K2 anticoagulated venous blood and sodium citrate anticoagulated venous blood and handmade method (P <0.05). The sodium citrate anticoagulated venous blood and manual method The results showed no significant difference (P> 0.05); and, EDTA-K2 anticoagulation venous blood platelets continued to decline over time. Conclusion: EDTA-K2 anticoagulants can cause platelet aggregation in some patients, leading to a significant decrease in platelet count. In this case smear staining microscopy confirmed, and sodium citrate anticoagulant venous blood platelets.