目的：前瞻性对比研究洛赛克和雷尼替丁对消化性溃疡的治愈率和ＨＰ的清除率。方法：７０例ＨＰ阳性的消化性溃疡患者，随机分成洛赛克组３８例和雷尼替丁组３２例。洛赛克组每日晨服２０ｍｇ＋抗菌药，治疗２周后改为洛赛克继续治疗４周。雷尼替丁组每日早晚各口服１５０ｍｇ＋抗菌药，治疗２周后用雷尼替丁继续治疗４周。结果：洛赛克组溃疡治愈率９４７４％，ＨＰ清除率９２１０％，雷尼替丁组溃疡治愈率７８１２％，清除率５６２５％。结论：洛赛克是治疗消化性溃疡极有效的药物，洛赛克对溃疡的近期疗效和ＨＰ清除率明显优于雷尼替丁。 OBJECTIVE: To prospectively compare the cure rates of cesis and ranitidine for peptic ulcer and clearance rate of HP. Methods: Seventy HP positive peptic ulcer patients were randomly divided into Losec group (n = 38) and ranitidine group (n = 32). Losec group daily morning service 20mg + antibacterials, treatment for 2 weeks to Losec continue treatment for 4 weeks. The ranitidine group was orally administered with 150 mg of antibacterial drug daily in the morning and evening and continued treatment with ranitidine for 2 weeks after 4 weeks of treatment. Results: The curative rate of ulceration was 9474% in Losec group, 9210% in HP group, 7812% in ranitidine group, and 5625% in ranitidine group. Conclusion: Losec is an extremely effective drug for the treatment of peptic ulcer. Losec’s immediate effect and HP clearance rate on ulcer are obviously better than that of ranitidine.