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Notch基因最早于1919年通过对果蝇基因的研究中被发现,该基因的部分功能缺失会在果蝇翅膀的边缘造成一些缺口(Notch)。人类Notch-1最早是在染色体异常[t(7;9)(q34;q34.3)]的T细胞白血病/淋巴瘤的细胞中被发现的,最初被命名为转位相关性Notch类似物-1(TAN-1),后来学者们在人造血
The earliest Notch gene was discovered in a 1919 study of Drosophila melanogaster genes. Partial loss of this gene caused some Notch at the edges of Drosophila wings. Human Notch-1 was first found in cells of T-cell leukemia / lymphoma with chromosomal abnormalities [t (7; 9) (q34; q34.3)] and was originally named as a translocation-related Notch analogue- 1 (TAN-1), then scholars in human blood