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目的探讨慢性乙型肝炎和肝硬化患者血清GP73(高尔基体蛋白-73)、IV-C(IV型胶原)和HA(透明质酸)水平与肝功能指标的关系。方法选择收治的慢性乙型肝炎合并肝硬化患者58例为肝硬化组,慢性乙型肝炎未发生肝硬化患者58例为肝炎组,门诊健康体检人群58例为健康组,比较3组患者血清GP73、IV-C和HA水平与肝功能指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、胆红素(TBIL)]的关系。结果肝硬化组ALT、AST、ALP、TBIL水平及GP73、IV-C、HA水平均显著高于肝炎组和健康组(P<0.05);肝炎组ALT、AST、ALP、TBIL水平及均GP73、IV-C、HA水平显著高于健康组(P<0.05)。结论慢性乙型肝炎和肝硬化患者血清GP73、IV-C和HA水平升高,肝功能指标亦升高,表示患者肝功能损害呈加重状态。
Objective To investigate the relationship between serum levels of GP73 (Golgi apparatus protein -73), IV-C (type IV collagen) and HA (hyaluronic acid) and liver function in patients with chronic hepatitis B and cirrhosis. Methods Fifty-eight patients with chronic hepatitis B and cirrhosis who were admitted to our hospital were selected as the cirrhosis group, 58 patients with chronic hepatitis B who did not develop cirrhosis as hepatitis group, and 58 healthy people as the health examination group. The serum GP73 , IV-C and HA levels and liver function indicators [ALT, AST, ALP, TBIL]. Results The levels of ALT, AST, ALP and TBIL and the levels of GP73, IV-C and HA in cirrhosis group were significantly higher than those in hepatitis group and healthy group (P <0.05). The levels of ALT, AST, IV-C, HA levels were significantly higher than the healthy group (P <0.05). Conclusion Serum GP73, IV-C and HA levels are elevated in patients with chronic hepatitis B and cirrhosis, and the indexes of liver function are also elevated, which indicates that patients with liver dysfunction are exacerbated.