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目的探讨总胆红素(TB)水平与DR的关系。方法选取T2DM患者553例,根据眼底检查结果分为无视网膜病变(NDR)组262例、视网膜病变(DR)组153例和增殖期DR(PDR)组138例。比较各组一般资料及TB水平,并进行分析。结果 DR组TB水平低于NDR组,高于PDR组,两组间比较差异有统计学意义(P<0.01或P<0.05)。Logistic回归分析显示,TB为DR的保护因素(OR=0.909,95%CI:0.876~0.943,P=0.005)。结论 TB水平与T2DM患者DR进程呈负相关。
Objective To investigate the relationship between total bilirubin (TB) and DR. Methods 553 T2DM patients were selected and divided into 262 cases without retinopathy (NDR), 153 cases with retinopathy (DR) and 138 cases with proliferative phase DR (PDR) according to the results of fundus examination. General information and TB levels were compared and analyzed. Results The level of TB in DR group was lower than that in NDR group and higher than that in PDR group. The difference between the two groups was statistically significant (P <0.01 or P <0.05). Logistic regression analysis showed that TB was the protective factor of DR (OR = 0.909, 95% CI: 0.876-0.943, P = 0.005). Conclusion The level of TB is negatively correlated with the DR progression of T2DM patients.