利用间接免疫荧光法监测291例接种狂犬疫苗后免疫效果,发现国产狂犬疫苗常规五针免疫的成功率为74.91％,未成功的采用3—5针加强免疫,可增加18.82％的人得到保护,从而使临床保护率提高到93.73％。阐明了免疫学效果监测的意义及国产疫苗现行的免疫程序与注射剂量存在的问题,并提出国产狂犬疫苗应增加疫苗内有效抗原成份,明确标出抗原含量(国际单位)或增加针次和常规开展免疫学监测及尽快研制高效价、短疗程、长效期的狂犬疫苗。 Indirect immunofluorescence method was used to monitor the immunogenicity of 291 rabies vaccines. The success rate of routine five-dose immunization with rabies vaccines was 74.91%. The unsuccessful vaccination with 3-5 doses boosted 18.82% So that the clinical protection rate increased to 93.73%. The significance of immunological monitoring and the current immunization procedure and injection dosage of domestic vaccines are clarified. It is also suggested that domestic rabies vaccines should increase effective antigens in vaccines, clearly indicate the antigen content (SI) or increase the number of needles and routine Carry out immunological surveillance and develop rabies vaccine with high titer, short course and long-term as soon as possible.