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用新疆产紫草根的短吋煎液进行了多方面的药理研究,发現不論对健康家兔及蟾蜍之离体或是整体心脏,皆有明显的兴奋作用;受烏拉坦抑制下的离体心脏亦有此反应。对家兔的实验性发燒,口服紫草煎液有緩和的解热作用。以上两种作用可能就是中医所謂的凉血、活血、透疹、解毒的作用基础。建議临床研究其对发疹及热性病的疗效。在全身麻醉下靜注或肌注紫草煎液,能使近半数的实驗动物(兔、犬、猫)血压急剧下降甚而死亡,但对不麻醉以及局麻下测量血压的动物,虽有个別降压,但未見此严重反应。据推断,这很可能是被全身麻醉所增强了的粗制剂的非特殊性过敏样反应。口服不会发生。对于家兔离体子宮及小腸平滑肌,紫草煎液有不恒定的兴奋作用,子宮以妊娠者较敏感。口服煎液能加强小腸的紧張性与收缩,靜注則无此反应。紫草煎液对实驗动物之心电图、呼吸、血管、血象,血糖、凝血时間、尿量及尿成分无特殊影响。
A variety of pharmacological studies were conducted using the short-brown decoction of Lithospermum roots produced in Xinjiang and it was found that both healthy rabbits and quail were isolated and the whole heart was excitable; The heart also has this reaction. For experimental fever in rabbits, oral Lithospermum decoction has a mild antipyretic effect. The above two effects may be the basis for the so-called cooling blood, blood circulation, rash, and detoxification of traditional Chinese medicine. It is recommended that clinical studies be conducted on the efficacy of rash and heat sickness. Under general anesthesia, intravenous or intramuscular injection of Lithospermum decoction can drastically reduce blood pressure and even death in nearly half of experimental animals (rabbits, dogs, and cats), although there is a measure of blood pressure in animals that are not anesthetized and under local anesthesia. Do not step down, but no serious reaction has been seen. It is postulated that this is likely to be a non-specific allergic reaction in crude preparations that have been boosted by general anesthesia. Oral does not occur. For isolated rabbit uterus and small intestine smooth muscle, Lithospermum decoction has a constant stimulatory effect, and the uterus is more sensitive to pregnancy. Oral decoction can strengthen the tension and contraction of the small intestine, intravenous injection is no such reaction. Lithospermum decoction has no special effect on the electrocardiogram, respiration, blood vessels, blood, blood glucose, clotting time, urine volume and urine composition of experimental animals.