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对中药通过调控葡萄糖转运蛋白4(glucose transporter 4,GLUT4)转位而改善胰岛素抵抗(insulin resistance,IR)的研究进展进行总结。GLUT4转位研究对IR的机制研究以及药物作用靶点的选择都具有重要意义。本文主要从磷脂酰肌醇3-激酶/非典型蛋白激酶C/蛋白激酶B(PI3K/PKC/Akt),AMP活化蛋白激酶(AMP-activated protein kinase,AMPK)等关键途径,介绍各种中药活性成分、单方及复方通过调控GLUT4转位对IR的改善作用及机制,为防治IR中药的临床合理使用及新药开发提供参考。
The research progress of traditional Chinese medicine (TCM) on improving insulin resistance (IR) through the regulation of glucose transporter 4 (GLUT4) translocation is summarized. GLUT4 translocation research on the mechanism of IR as well as the choice of drug targets are of great significance. This article mainly introduces various kinds of traditional Chinese medicine activity from key pathways such as phosphatidylinositol 3-kinase / atypical protein kinase C / protein kinase B (PI3K / PKC / Akt) and AMP-activated protein kinase (AMPK) Components, unilaterally and synthetically, provide reference for the prevention and treatment of clinical use of IR traditional Chinese medicine and the development of new drugs by regulating the effect and mechanism of GLUT4 translocation on IR.