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1型糖尿病是与遗传有关的自身免疫性疾病。近年来在主要组织相容抗原复合物Ⅱ(MHC Ⅱ)类区域发现的抗原处理相关转运体基因(TAP)参与内源性抗原的递呈,在自身免疫性疾病中起重要作用。本文采用家系遗传学调查法———传递与不平衡检验(TDT)对1型糖尿病家系各TAP基因单倍型的传
Type 1 diabetes is a genetically related autoimmune disease. In recent years, antigen-related transporter (TAP) genes found in major histocompatibility complex Ⅱ (MHC Ⅱ) regions are involved in the presentation of endogenous antigens and play an important role in autoimmune diseases. In this paper, the family genetics survey --- transmission and imbalance test (TDT) of type 1 diabetes pedigree of the TAP gene haplotype