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本文报道了用HPLC法测定抗心血管病药物硝苯吡啶及有关化合物的油水分配系数(P);并将实验值和理论值作了比较,大多数化合物的误差小于10%;符合目前用高效液相法测定logP值所允许的误差范围。
This paper reports the determination of the oil-water partition coefficient (P) of anti-cardiovascular drug nifedipine and its related compounds by HPLC. The experimental values and theoretical values are compared, and the error of most compounds is less than 10% The allowable error range of the logP value measured by liquid phase method.