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电离辐射后动物小肠组织中乙酰胆硷(Ach)含量增高可能是引起肠道运动功能紊乱的原因之一。研究照射后肠道组织中ACh含量变化对于阐明肠道运动功能紊乱原因及其防治具有一定的意义。正常情况下,小肠组织中胆硷乙酰转移酶(ChAT)和胆硷酯酶(ChE)活性是维持ACh含量恒定的主要因素。Conard曾报道X线600rad照射后的大鼠小肠组织中ChE活性降低到40%。我们也观察到丙线照射后小鼠小肠组织中ChE活性降低到40—50%,而ACh含量却大幅度增高,但是ChE活性降低和ACh含量增高的
The increase of acetylcholine (Ach) content in the intestinal tissues of the animals after ionizing radiation may be one of the causes of intestinal motility disorders. Studying the changes of ACh in intestinal tissue after irradiation has some significance for elucidating the causes of intestinal motility disorders and their prevention and treatment. Under normal circumstances, small intestine tissue choline acetyltransferase (ChAT) and cholinesterase (ChE) activity is to maintain a constant ACh main factor. Conard reported reduction in ChE activity to 40% in rat intestinal tissue following 600-ray X-ray irradiation. We also observed that the activity of ChE decreased to 40-50% in the small intestine of mice after irradiation with C, while the content of ACh increased significantly, but the activity of ChE decreased and the content of ACh increased