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链霉素(SM)最先用于肺结核的治疗,能有效地改善病人的临床症状,但连用几个月后,结核菌常对SM 产生耐药性,以致治疗无效.后来发现SM 与PAS(对氨水杨酸)联用,可降低该菌对SM 的耐药性,长期联用甚至可防止耐药性产生,疗效良好.此外还发现长期联用SM、INH(异烟肼)和PAS 能将空洞型肺结核治愈.【结核菌耐药性产生机理及其防治措施】结核菌因基因突变对各种抗结核药可能产生耐药,其发生率:RFP(利福平)为10~(-8);INH、SM、KM(卡那霉素)、PAS 及
Streptomycin (SM) was first used in the treatment of pulmonary tuberculosis, can effectively improve the patient’s clinical symptoms, but after several months of continuous use, M. tuberculosis often produce resistance to SM, resulting in ineffective treatment was later found SM and PAS ( On the combination of ammonia salicylic acid), can reduce the bacteria resistance to SM, long-term combination can prevent the generation of drug resistance, good effect.In addition also found that long-term combination of SM, INH (isoniazid) and PAS can Will be cured of empty tuberculosis.】 【Mechanism of TB drug resistance and prevention and control measures TB mutations due to genetic mutations may cause a variety of anti-TB drugs, the incidence rate: RFP (rifampicin) 10 ~ (- 8); INH, SM, KM (kanamycin), PAS and