室安卡因(tocainide)是一种类似于利多卡因的新型口服药物,用以治疗室性心律失常有效。本文报道1例于首次服用室安卡因后4周发生致死性粒细胞缺乏症。患者男性,62岁。于1973年患急性心肌梗塞继发双心室充血性心力衰竭。1981年出现复发性持久性室性心动过速。开始服用慢心利,共18个月,治疗期间白细胞数为5。300～6,500/mm~3,分类正常。因出现恶心、头痛和疲劳停用慢心利。改服室安卡因,开始剂量为(?)00mg 每天3次,几天后因出现恶心,剂量减为400mg 每天3次,恶心缓解。服用室安卡因1周后, Tocainide is a new oral drug similar to lidocaine used to treat ventricular arrhythmias. This article reports 1 case of lethal granulocytic deficiency 4 weeks after the first dose of ventricular card anemia. Male patient, 62 years old. In 1973 suffering from acute myocardial infarction secondary to biventricular congestive heart failure. Recurrent persistent ventricular tachycardia in 1981. Start taking slow heart-benefit, a total of 18 months, the number of white blood cells during treatment 5.300 ~ 6,500 / mm ~ 3, normal classification. Because of nausea, headache and fatigue to disable slow hearted Lee. Room service room ancain, the initial dose of (?) 00mg 3 times a day, due to nausea after a few days, the dose was reduced to 400mg 3 times a day, nausea relief. After taking room anaine for 1 week,