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目的探讨中老年人十年缺血性心血管病发病绝对危险度的影响因素。方法选取2007年1月—2015年5月在江苏省南通市妇幼保健院进行体检的中老年人1 642例,根据《十年缺血性心血管病发病绝对危险度评估表》评估结果分为低度组895例、中度组411例及高度组336例,比较3组患者临床资料,并采用Cox比例风险回归模型分析筛选中老年人十年缺血性心血管病发病绝对危险度的影响因素。结果 3组中老年人性别、吸烟史阳性率、高血压发生率、糖尿病发生率、冠心病或其他心血管疾病发生率、脑梗死发生率及年龄、BMI、收缩压、舒张压、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)比较,差异均有统计学意义(P<0.05)。Cox比例风险回归模型分析结果显示,BMI〔RR=1.462,95%CI(1.123,1.542)〕、收缩压〔RR=1.234,95%CI(1.012,0.432)〕、TC〔RR=1.452,95%CI(1.234,1.567)〕、TG〔RR=1.205,95%CI(1.025,1.714)〕、LDL-C〔RR=2.134,95%CI(1.956,2.342)〕、HDL-C〔RR=1.327,95%CI(1.167,2.041)〕是中老年人十年缺血性心血管病发病绝对危险度的影响因素(P<0.05)。结论 BMI、收缩压、TC、TG、LDL-C及HDL-C是中老年人十年缺血性心血管病发病绝对危险度的危险因素,应进行针对性干预。
Objective To explore the influencing factors of absolute risk of 10-year ischemic cardiovascular disease in the elderly. Methods From January 2007 to May 2015, 1 642 middle-aged and elderly people were examined in Nantong Maternal and Child Health Hospital of Jiangsu Province. According to the assessment results of “absolute risk assessment table of onset of 10-year ischemic cardiovascular disease” 895 cases in the low group, 411 cases in the moderate group and 336 cases in the height group. The clinical data of the three groups were compared and analyzed by Cox proportional hazards regression model to analyze the influence of the absolute risk of ten-year ischemic cardiovascular disease factor. Results The gender, smoking history positive rate, incidence of hypertension, incidence of diabetes, incidence of coronary heart disease or other cardiovascular diseases, incidence of cerebral infarction and age, BMI, systolic blood pressure, diastolic blood pressure, triglyceride TG, TC, LDL-C, HDL-C and FPG were significantly different (P <0.05) . Cox proportional hazards regression analysis showed that BMI (RR = 1.462, 95% CI 1.123, 1.542), systolic blood pressure (RR 1.234, 95% CI 1.012, 0.432) (RR = 1.205,95% CI (1.025,1.714)], LDL-C [RR = 2.134,95% CI (1.956,2.342)], HDL-C [RR = 1.327, 95% CI (1.167,2.041)] is the influencing factor of the absolute risk of 10-year ischemic cardiovascular disease in the elderly (P <0.05). Conclusions BMI, systolic blood pressure, TC, TG, LDL-C and HDL-C are risk factors of absolute risk of 10-year ischemic cardiovascular disease in the elderly, and targeted intervention should be carried out.