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目的:探讨HBV感染患儿外周血T淋巴细胞亚群的特点。方法:流式细胞仪检测正常对照组和乙型肝炎患者外周血淋巴细胞CD8 CD28表达。结果;HBV感染儿童CD8+CD28+T淋巴细胞明显高于健康儿童(P<0.05),培养后慢性乙型肝炎轻中度患者CD8+CD28+T淋巴细胞明显低于直接检测(P<0.05),而CD8+CD28-T淋巴细胞明显高于直接检测(P<0.05)。结论:CD8 CD28表达情况可以作为判断儿童HBV感染患病情况的重要参考依据。
Objective: To investigate the characteristics of peripheral blood T lymphocyte subsets in children with HBV infection. Methods: Flow cytometry was used to detect CD8 CD28 expression in peripheral blood lymphocytes of normal control group and Hepatitis B patients. Results CD8 + CD28 + T lymphocytes in HBV-infected children were significantly higher than those in healthy children (P <0.05). CD8 + CD28 + T lymphocytes in patients with mild to moderate chronic hepatitis B were significantly lower than those in HBV-infected children (P <0.05) , While CD8 + CD28-T lymphocytes were significantly higher than those detected directly (P <0.05). Conclusion: The expression of CD8 CD28 may be used as an important reference for judging the prevalence of HBV infection in children.