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对128例大肠癌根治术标本进行CEA免疫组织化学观察。结果发现,大肠正常粘膜及癌旁粘膜CEA阳性率分别为7.7%与23.8%,其反应强度较弱,且仅出现于腺腔缘;而癌组织中CEA阳性率为96.9%,反应通常较强,除在腺腔缘外还出现于胞浆及胞膜。CEA反应强度和定位方式与肿瘤分化程度密切相关。高分化癌CEA反应多较弱,常呈腺腔缘表达;而中低分化癌反应多较强,常呈胞浆胞膜表达。CEA定位方式比其反应强度具有更重要的临床病理学意义。
The CEA immunohistochemical observation was performed on 128 cases of colorectal cancer. The results showed that the positive rates of CEA in normal mucosa and paraneoplastic mucosa of the colon were 7.7% and 23.8%, respectively. The response intensity was weak, and it only appeared in the margin of the gland. The positive rate of CEA in the cancer tissue was 96.9%, and the response was usually strong. In addition to the edge of the gland, it also appears in the cytoplasm and membrane. The intensity and location of CEA response are closely related to the degree of tumor differentiation. CEA in well-differentiated carcinomas is often weak, and it is often expressed in the margins of the adenocarcinoma. However, the moderately-differentiated carcinomas are more reactive and often show cytoplasmic membrane expression. CEA positioning has more important clinical pathological significance than its response intensity.