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目的探讨脂联素和瘦素与抗精神病药物致脂代谢紊乱的关系。方法测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、脂联素(Adi)和瘦素(leptin)水平,测量身高和体质量,采用聚合酶链扩增和限制性片段长度多态性技术测定脂联素基因多态性。结果 (1)治疗前后对比,BMI、TG、LDL、Leptin和TC水平均显著增高(P<0.01,P<0.05),而Adi水平则显著降低(P<0.05);(2)治疗后,脂联素基因+45G/X基因型者BMI、TG和LDL较治疗前均显著升高(P<0.01),Adi较治疗前则显著下降(P<0.05),而T/X基因型者治疗前后各项指标无显著变化(P>0.05)。结论抗精神病药物可引起体内脂联素水平降低和瘦素水平升高;脂联素+45位G基因是抗精神病药物致脂代谢紊乱的一个危险因素
Objective To investigate the relationship between adiponectin and leptin and lipid metabolism induced by antipsychotic drugs. Methods The levels of serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), adiponectin (Adi) and leptin were measured. Quality, Adiponectin gene polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphism. Results (1) Before and after treatment, BMI, TG, LDL, Leptin and TC levels were significantly increased (P <0.01, P <0.05), while Adi levels were significantly lower (P < The BMI, TG and LDL of the genotype + 45G / X genotype were significantly higher than those before treatment (P <0.01), and Adi was significantly lower than that before treatment (P <0.05), while those with T / X genotype No significant changes in the indicators (P> 0.05). Conclusion Antipsychotic drugs can cause a decrease of adiponectin level and increase of leptin level. Adiponectin +45 G gene is a risk factor of antipsychotic drug induced lipid metabolism disorders