3,4-二羟基苯乙酮(DHAP)俸内体外给药,都明显抑制胶原或花生四烯酸诱导家兔血小板释放的血栓素B_2含量,剂量与效应相关,生物测定法与放射免疫分析所得结果相平行。实验结果还表明,AA较胶原诱导血小板释放TXB_2量强3～6倍。如不加诱导剂,血小板自发性释放TXB_2量甚微。此外,DHAP抑制AA诱导血小板释放TXB_2的作用也较胶原诱导时为强。DHAP是环加氧酶抑制剂,还是TXA_2合成酶抑制剂,有待进一步证实。 3,4-dihydroxyacetophenone (DHAP), both in vitro and in vivo, significantly inhibited the release of thromboxane B2 from rabbit platelets induced by collagen or arachidonic acid. The dosage was related to the effect. Bioassay and radioimmunoassay The results are parallel. The experimental results also show that, compared with collagen-induced release of TXB 2 platelets 3 to 6 times stronger. Without additional inducers, the amount of spontaneous release of TXB2 on platelets was negligible. In addition, the effect of DHAP on AA-induced platelet release of TXB_2 was also stronger than that induced by collagen. DHAP is a cyclooxygenase inhibitor, or TXA 2 synthase inhibitor, to be further confirmed.