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采用双抗体夹心法及抗体致敏的红细胞花环法对７０例胃癌患者血清可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）水平及外周血Ｔ淋巴细胞亚群进行检测。结果表明，胃癌患者血清中ｓＩＬ－２Ｒ水平较正常对照组明显增高（Ｐ＜０．００１），但胃癌Ⅰ～Ⅱ期与Ⅲ～Ⅳ期患者血清中ｓＩＬ－２Ｒ水平无明显差异（Ｐ＞０．０５）。胃癌患者外周血Ｔ淋巴细胞亚群ＣＤ_３、ＣＤ_４及ＣＤ_４／ＣＤ_８比值明显低于正常对照组（Ｐ＜０．０１）．提示胃癌患者存在免疫功能的失调，外周血ＣＤ_３、ＣＤ_４减少与ｓＩＬ－２Ｒ水平增高有一定的关系，同时也在一定程度上为使用大剂量ＩＬ－２治疗晚期肿瘤患者取得一定疗效提供理论依据。
Serum soluble interleukin 2 receptor (sIL-2R) levels and peripheral blood T lymphocyte subsets were detected in 70 patients with gastric cancer by double antibody sandwich method and antibody-sensitized red blood cell garland method. The results showed that the serum levels of sIL-2R in gastric cancer patients were significantly higher than those in normal controls (P<0.001), but there was no significant difference in serum sIL-2R levels between patients with stage I-II and stage III-IV (P>0). .05). The ratios of CD3, CD4 and CD4/CD8 in peripheral blood of gastric cancer patients were significantly lower than those in normal controls (P<0.01). It is suggested that there is a disorder of immune function in gastric cancer patients. The decrease of CD3 and CD4 in peripheral blood is related to the increase of sIL-2R, and it also provides a theoretical basis for the use of high-dose IL-2 in the treatment of advanced cancer patients to a certain extent.