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母鼠及子鼠饮用含氯化锰（２ｇ／Ｌ或１０ｇ／Ｌ）的水，研究锰对大鼠子代行为和脑锥体外系发育的影响。结果显示：（１）在“ＥｌｅｖａｔｅｄＰｌｕｓＡｒｍｓＭａｚｅ”迷宫测试中，染锰组仔鼠从中央区进入第一臂的潜伏期缩短，但进入开放臂的次数与对照组无差异；在Ｍｏｒｒｉｓ水迷宫肌力测试中，各组动物仔鼠到达平台的时间无差异。（２）高剂量染锰组尾状核和伏隔核的面积、胶质细胞纤维酸蛋白免疫反应强度及反应阳性产物的平均相对密度均较对照组显著升高；（３）高剂量组仔鼠黑质、中脑腹侧被盖区和尾状核的酷氨酸氢氧化酶免疫反应强度及其反应阳性产物的平均相对密度均比对照组明显下降。
Maternal and offspring drinking manganese chloride (2g / L or 10g / L) of water to study the effects of manganese on the offspring of rats and the development of extracerebral brain. The results showed that: (1) In the “ElevatedPlusArmsMaze” maze test, the latency of entering pups from the central area to the first arm was shortened, but there was no difference between the number of open arms and the control group; in the Morris water maze test There was no difference in the time between the groups of animals and pups reaching the platform. (2) The area of caudate nucleus and nucleus accumbens, the glial fibrillary acidic protein immunoreactivity and the average relative density of the reaction-positive products in high-dose Mn-Zn-treated group were significantly higher than those in control group. (3) Compared with the control group, the intensity of tyrosine hydroxylase immunoreactivity and the average relative density of the reaction-positive products in the substantia nigra, midbrain ventral tegmental area and caudate nucleus were significantly decreased.