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研究证明许多组织的生长受激素调节,由这些组织所发生的肿瘤也依然受这些激素的控制.一些胃肠激素可刺激胃肠道细胞的增殖和分化,同时也具有促进部分胃肠道肿瘤生长的作用.胃癌细胞可产生和分泌某些胃肠激素,通过其细胞膜上的相应受体激活细胞内信号传递途径,发挥调节肿瘤生长作用,并可致周围血中这些激素水平发生变化.我们通过检测胃癌组织、癌旁粘膜以及癌区动、静脉血,周围血中促胃液素、胰高糖素及胃动素之含量,旨在研究这几种胃肠激素在癌区组织及血液中的变化特点,探讨胃肠激素与胃癌的关系.1 材料和方法1.1 材料共44例,男27例,女17例,中位年龄58(33～82)
Studies have shown that the growth of many tissues is regulated by hormones and the tumors that occur in these tissues are still controlled by these hormones.Some gastrointestinal hormones can stimulate the proliferation and differentiation of gastrointestinal cells and also promote the growth of some gastrointestinal tumors The role of gastric cancer cells can produce and secretion of certain gastrointestinal hormones, through the corresponding receptors on the cell membrane activation of intracellular signaling pathway, play a role in regulating tumor growth, and can cause peripheral blood levels of these hormones change we passed Detection of gastric cancer, adjacent mucosa and cancerous area of the arterial and venous blood, peripheral blood gastrin, glucagon and motilin levels, to study these types of gastrointestinal hormones in cancer tissue and blood Changes in characteristics and explore the relationship between gastrointestinal hormones and gastric cancer.1 Materials and Methods 1.1 Materials, a total of 44 cases, 27 males and 17 females, the median age of 58 (33 to 82)