Objective:The aim of this study was to study the expression and the clinical pathological relationship of p27 and Skp2 in the tissues of colorectal cancer,discuss the correlation between them.Methods:To determine the expressions of p27 and Skp2 among 30 cases of colorectal cancer tissue specimen and 18 cases of normal colorectal tissue samples with immunohistochemistry SP method.Results:The average positive rate of p27 among the normal colorectal tissue samples was 55.2%,which was obviously higher than that of colorectal cancer tissue samples(27.5%,P < 0.05).The correlation between the expression of p27 and the degree of differentiation of colorectal cancer;Dukes stage and lymph node metastasis were distinctly negative(P < 0.05).The average positive rate of Skp2 among the colorectal cancer tissue specimens was 9.5%,which was obviously higher than that of normal colorectal tissue samples(1.8%,P < 0.05).There was an obviously negative correlation between the expression of Skp2 and the degree of differentiation of colorectal cancer(P < 0.05),and the expression of Skp2 had no significant correlation with patients’ age,sex,Dukes stage and lymph node metastasis(P > 0.05).There was an negative correlation between the expression of p27 and Skp2(r =-0.806,P < 0.01).Conclusion:The expression of Skp2 in the colorectal cancer tissues is correlative with the degradation of p27;Skp2,the oncogene of colorectal cancer,is involved in colorectal carcinogenesis,which may be the new target for the treatment of colorectal cancer. Objective: The aim of this study was to study the expression and the clinical pathological relationship of p27 and Skp2 in the tissues of colorectal cancer, discuss the correlation between them. Methods: To determine the expressions of p27 and Skp2 among 30 cases of colorectal cancer tissue specimens and 18 cases of normal colorectal tissue samples with immunohistochemistry SP method. Results: The average positive rate of p27 among the normal colorectal tissue samples was 55.2%, which was obviously higher than that of colorectal cancer tissue samples (27.5%, P < 0.05). The correlation between the expression of p27 and the degree of differentiation of colorectal cancer; Dukes stage and lymph node metastasis were distinctly negative (P <0.05). The average positive rate of Skp2 among the colorectal cancer tissue specimens was 9.5% which was obviously higher than that of normal colorectal tissue samples (1.8%, P <0.05). There was an apparent negative correlation between the expression of Skp2 and the de gree of differentiation of colorectal cancer (P <0.05), and the expression of Skp2 had no significant correlation with patients’ age, sex, Dukes stage and lymph node metastasis (P> 0.05). There was an negative correlation between the expression of p27 and Skp2 (r = -0.806, P <0.01) .Conclusion: The expression of Skp2 in the colorectal cancer tissues is correlative with the degradation of p27; Skp2, the oncogene of colorectal cancer, is involved in colorectal carcinogenesis, which may be the new target for the treatment of colorectal cancer.