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[目的]探讨复方苦参注射液持续滴注联合肝动脉化疗栓塞(TACE)治疗原发性肝癌疗效。[方法]选择不宜手术的中晚期肝癌60例,随机分为治疗组和对照组各30例。治疗组:先行TACE术,术后第2天行外周中心静脉置管(PICC),连接化疗泵,每日持续24h静脉滴注复方苦参注射液20mL,持续14天,共15天为1个疗程,每疗程间隔15天,共治疗2个疗程;对照组:行TACE术治疗1次为1个疗程,每疗程间隔1个月,共治疗2个疗程。2个疗程结束时治疗组和对照组进行疗效评价。[结果]肿瘤稳定率、缓解肝区疼痛、腹胀及提高生存质量方面,治疗组优于对照组,两组比较有显著性差异。[结论]复方苦参注射液持续静滴联合肝动脉化疗栓塞能一定程度上稳定肿瘤生长,改善症状和提高生活质量。
[Objective] To investigate the curative effect of compound Kushen injection continuous infusion combined with transcatheter arterial chemoembolization (TACE) in the treatment of primary liver cancer. [Methods] Sixty cases of advanced hepatocellular carcinoma that were not suitable for operation were randomly divided into treatment group (30 cases) and control group (30 cases). In the treatment group, TACE was performed first, followed by peripheral central venous catheterization (PICC) on the second day after the operation. A chemotherapy pump was connected to the vein and 20 mL of Compound Kushen Injection was administered intravenously daily for 14 days for a total of 15 days Course of treatment, each treatment interval of 15 days, a total of 2 courses of treatment; control group: TACE line 1 treatment for a course of treatment, each treatment interval of 1 month, a total of 2 courses of treatment. At the end of two courses, the treatment group and the control group were evaluated. [Results] The treatment group was superior to the control group in terms of the stability of the tumor, alleviating the pain in the liver area, bloating and improving the quality of life. There was a significant difference between the two groups. [Conclusion] Compound Kushen injection continuous intravenous infusion combined with transcatheter arterial chemoembolization can stabilize tumor growth to a certain extent, improve symptoms and improve quality of life.