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目的探讨Ⅰ期非小细胞肺癌(NSCLC)患者的诊断与治疗。方法回顾性分析我院1991年至2004年226例I期NSCLC的诊疗经过。全组肺叶切除206例,肺段或楔形切除15例,袖状切除5例。结果无围手术期死亡,Ⅰ期NSCLC患者的1、3、5年生存率分别为93.6%、80.3%和66.2%。鳞癌的1、3、5年生存率均比腺癌与腺鳞癌患者的1、3、5年生存率高(P<0.05)。肺叶切除患者的1、3、5年生存率比肺段或楔形切除患者高(P<0.05)。结论定期体检及综合检查对Ⅰ期肺癌的早期发现与诊断极为重要。外科治疗可以获得很好的疗效,肺叶切除加纵隔淋巴结清扫是早期肺癌的有较好预后的治疗方案。
Objective To investigate the diagnosis and treatment of stage Ⅰ non-small cell lung cancer (NSCLC). Methods A retrospective analysis of our hospital from 1991 to 2004, 226 cases of stage I NSCLC diagnosis and treatment. 206 cases of lobectomy, pulmonary section or wedge resection in 15 cases, sleeve resection in 5 cases. Results There were no perioperative deaths. The 1, 3, 5 year survival rates of patients with stage I NSCLC were 93.6%, 80.3% and 66.2%, respectively. The 1, 3, 5-year survival rates of squamous cell carcinoma were significantly higher than those of adenocarcinoma and adenosquamous carcinoma at 1, 3 and 5 years (P <0.05). The 1, 3, 5 year survival rate of patients with lobectomy was higher than that of patients with segmental or wedge resection (P <0.05). Conclusion Regular physical examination and comprehensive examination of early detection and diagnosis of stage I lung cancer is extremely important. Surgical treatment can get good results, lobectomy and mediastinal lymph node dissection is a better prognosis of early lung cancer treatment options.