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目的:分析孕妇伴乙型肝炎病毒(HBV)感染对新生儿及妊娠结局的影响。方法:选取2013年1月—2014年12月间分娩的孕期伴有HBV感染孕妇156例作为研究对象,将其分为乙肝表面抗原(HBs Ag)阳性的96例作为单阳组,HBs Ag和乙型肝炎e抗原(HBe Ag)均为阳性的60例作为双阳组,并选择同期无HBV感染孕妇70例作为对照组,分析与比较孕妇妊娠结局的相关因素。结果:双阳组孕妇中肝功能异常者发生妊娠期高血压疾病、肝内胆汁淤积症及产后出血率均高于单阳组及对照组(P<0.05);胎膜早破、早产、新生儿窒息和低体质量儿的发生率均高于对照组(P<0.05);单阳组与对照组孕妇间母婴并发症经比较其差异无统计学意义(P>0.05)。结论:孕妇HBV感染双阳性者可引起肝损害并增加妊娠期高血压疾病、肝内胆汁淤积症、产后出血、胎膜早破、早产、新生儿窒息、低体质量儿的发生率对母婴的影响较大,应加强孕妇产前检查及妊娠期并发症的防治。
Objective: To analyze the influence of pregnant women with hepatitis B virus (HBV) infection on newborns and pregnancy outcomes. Methods: One hundred and sixty-six pregnant women with HBV infection during pregnancy during January 2013 to December 2014 were selected and divided into 96 positive HBsAg positive patients as HBs Ag, Sixty cases with HBeAg positive were selected as Shuangyang group. Seventy pregnant women without HBV infection were selected as the control group, and the related factors of pregnancy outcome were analyzed and compared. Results: Hypertensive disorders in pregnancy, intrahepatic cholestasis and postpartum hemorrhage were both higher than those in the single positive group and the control group (P <0.05). The premature rupture of membranes, premature labor, newborn infants The incidence of asphyxia and low birth weight children were higher than that of the control group (P <0.05). There was no significant difference in maternal and infant complications between the single positive group and the control group (P> 0.05). Conclusions: Pregnant women with double positive HBV infection may cause liver damage and increase the incidence of hypertensive disorder complicating pregnancy, intrahepatic cholestasis, postpartum hemorrhage, premature rupture of membranes, premature birth, neonatal asphyxia and low birth weight. The impact of pregnancy should be strengthened prenatal care and prevention and treatment of complications during pregnancy.